Under the guidance of the TCM theory, we are researching on the big brand TCM which can demonstrate substance basis and mechanism of action of compound TCM treatment characteristic. In addition, our researches include prescription identification and compatibility regularity of big brand TCM. Relying on advanced technology, such as modern analysis and detection method, high-throughput screening, microfluidic chip, and gene-chip etc.; combining with research methods of modern “omics”, “network pharmacology” and “Q-marker”; we are establishing a research platform for secondary development big brand TCM, and achieving a series of innovative TCM research achievements with TCM characteristic, traceability, controlled quality, precise efficacy, and advanced dosage form.